02567nas a2200349   4500000000100000008004100001260001300042653001000055653002500065653001200090653003100102653001100133653002800144653001200172653001600184653002100200653002100221100001400242700001300256700001200269700001200281700001700293700001200310700001600322245006300338856005900401300001000460490000700470050003200477520169400509022001402203       1994                            d  c1994 Dec10aAdult10aCase-Control Studies10aFingers10aHand Deformities, Acquired10aHumans10aLaser-Doppler Flowmetry10aleprosy10aMiddle Aged10aSkin Temperature10aVasomotor System1 aAbbot N C1 aBeck J S1 aRao B B1 aFeval F1 aStanford J L1 aWeiss F1 aMobayen M H00aCirculation and sensation at the fingertips of claw hands.  uhttp://leprev.ilsl.br/pdfs/1994/v65n4/pdf/v65n4a07.pdf  a341-90 v65  aInfolep Library - available3 a<p>Measurements of skin blood flow (by laser Doppler flowmetry) and temperature were made under environmental conditions promoting peripheral vasodilatation at the fingertips of a disfigured 'clawed' hand in 12 leprosy patients long-resident at Baba Baghi Leprosy Hospital, Tabriz, Iran. Sensory function was assessed by measuring the responses to light touch, pain and temperature of each finger, and peripheral autonomic function was gauged by estimating palmer sweating and by measuring skin vasomotor reflexes in response to inspiratory gasp. In 2 patients all measured fingers had laser Dopper flux (LDFlux) values and skin temperatures lower than the 95% confidence limits for the mean of 20 healthy controls, i.e. were impaired; in 2 patients all fingers had normal values for LDFlux and temperature; and in 8 patients there was a combination of impairment with most fingers normal for these parameters but with the small finger most commonly impaired. There were 10 (67%) fingers with impaired LDFlux and temperature values who had significant sensory impairment, whereas only 5 (18%) of the fingers with normal LDFlux values and temperatures had a similar sensory deficit. Overall, the fingers with the most impaired sensation had significantly (P < 0.05) lower LDFlux and temperature values than those with no sensory deficit. Microcirculatory impairment was not related to disordered skin vasometer reflexes or dysfunction of sweating. We concluded that the relationship between motor (skeletal muscle) nerve paralysis and any subsequent sensory neuropathy and/or microcirculatory impairment is more complex than might be expected from previous understanding of the disease.</p>  a0305-7518