02495nas a2200397   4500000000100000008004100001260001300042653001500055653002600070653001000096653001800106653003800124653001100162653001600173653001100189653002300200653001000223653001900233653001300252653001200265653000900277653002500286653002600311100001300337700001500350700001300365700001700378700001500395245018200410856004100592300001100633490000700644050001700651520141500668022001402083       1994                            d  c1994 Dec10aAdolescent10aAntibodies, Bacterial10aChild10aDisaccharides10aEnzyme-Linked Immunosorbent Assay10aFemale10aGlycolipids10aHumans10aImmunity, Cellular10aIndia10aLeper Colonies10aLepromin10aleprosy10aMale10aMycobacterium leprae10aSerum Albumin, Bovine1 aShah D H1 aVartak R R1 aNaik S S1 aDandekar S R1 aGanapati R00aEpidemiological studies in children of a low-endemic region, a high-endemic region, and dwellers of a leprosy colony: evaluation of anti-ND-BSA antibodies and lepromin response.  uhttp://ila.ilsl.br/pdfs/v62n4a06.pdf  a539-460 v62  aSHAH1994 (2)3 a<p>Children residing in a low-endemic region (LER), a high-endemic region (HER), and a leprosy colony contact population (CP) were evaluated for lepromin response as well as reactivity to the Mycobacterium leprae-specific synthetic antigen, ND-BSA. The mean reactivity to ND-BSA in the LER group (OD 0.03 +/- 0.03, N = 71) was significantly lower (p &lt; 0.001) than that in the contact population (OD 0.14 +/- 0.09, N = 140) as well as the population residing in the HER (OD 0.09 +/- 0.08, N = 1340). ELISA-positive results were the highest (21.4%) with the CP group and lowest (0.0%) in the LER group, suggesting that it was a measure of the extent of exposure of M. leprae. In the contact population, females showed a preponderance for ELISA positivity over males (p &lt; 0.005), a finding not observed with the HER population. The Mitsuda responses showed a Gaussian-type distribution in all of the three populations examined with the mean response being highest in the LER (6.0 mm +/- 2.9) and lowest in the HER (4.5 mm +/- 2.0) groups. The percent positivity for the Mitsuda reaction was found to be highest in the LER (93.0%) and lowest in the HER (88.3%) groups. The Mitsuda response thus appears to be independent of M. leprae exposure, and its interpretation in a given population needs consideration of several factors, such as nutritional, environmental, etc.(ABSTRACT TRUNCATED AT 250 WORDS)</p>
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