01590nas a2200265   4500000000100000008004100001260001300042653000900055653002300064653001100087653002200098653001200120653000900132653002500141653002500166100001200191700001600203700001500219245008000234300001200314490000600326050001500332520096300347022001401310       1995                            d  c1995 Feb10aAged10aGlomerulonephritis10aHumans10aKidney Glomerulus10aleprosy10aMale10aMicroscopy, Electron10aMycobacterium leprae1 aAhsan N1 aWheeler D E1 aPalmer B F00aLeprosy-associated renal disease: case report and review of the literature.  a1546-520 v5  aAHSAN 19953 a<p>Leprosy is an infectious disease the principal clinical manifestations of which are anesthetic skin lesions and the development of peripheral neuropathy. The most common renal manifestation in leprosy patients is glomerulonephritis. Both immunofluorescent and electron microscopic studies suggest that the varied glomerular lesions found in these patients are immune complex mediated. Other renal lesions that have been described include amyloidosis, tubulointerstitial disease, acute renal failure, and functional defects in the absence of identifiable histologic abnormalities. In this report, a patient is described who developed the clinical syndrome of rapidly progressive glomerulonephritis. The renal biopsy showed a diffuse endocapillary proliferative process with electron-dense deposits in the glomerular subendothelial and subepithelial spaces. Organisms consistent with Mycobacterium leprae were identified within several of the glomeruli.</p>  a1046-6673