01505nas a2200265   4500000000100000008004100001260001300042653002600055653001100081653001200092653002500104653003200129653002000161100001400181700001700195700001600212700001500228245008800243856005900331300001000390490000700400050001600407520080200423022001401225       1995                            d  c1995 Mar10aAntibodies, Bacterial10aHumans10aleprosy10aMycobacterium leprae10aSensitivity and Specificity10aSerologic Tests1 aParkash O1 aChaturvedi V1 aGirdhar B K1 aSengupta U00aA study on performance of two serological assays for diagnosis of leprosy patients.  uhttp://leprev.ilsl.br/pdfs/1995/v66n1/pdf/v66n1a04.pdf  a26-300 v66  aPARKASH19953 a<p>We compared 2 serological tests for the diagnosis of leprosy to test their performances. The tests include the serum antibody competition test (SACT) for the detection of antibodies to Mycobacterium leprae-specific epitope on 35 KDa protein molecule, and M. leprae gelatin particle agglutination assay (MLPA), for the detection of antiphenolic glycolipid-1 (PGL-1) antibodies. In both the assays a higher serological positivity was seen amongst multibacillary (MB) patients than those in paucibacillary (PB) patients. Taking all leprosy patients together, the sensitivity of SACT (59.7%) was observed to be statistically comparable to that of MLPA (66.9%). However, SACT proved to be more specific (97.7%) than MLPA (75.0%). The agreement between these 2 assays was observed to be moderate.</p>  a0305-7518