01487nas a2200325   4500000000100000008004100001260001600042653002400058653000900082653004300091653001200134653002800146653003000174653001800204653001100222653001100233653001200244653001000256653000900266653001600275653001500291653002800306653001300334100001000347245012900357300001100486490000700497520064300504022001401147       1995                            d  c1995 May 2210aAcute Kidney Injury10aAged10aChemical and Drug Induced Liver Injury10aDapsone10aDiagnosis, Differential10aDrug Therapy, Combination10aFatal Outcome10aHumans10aKidney10aleprosy10aLiver10aMale10aMyocarditis10aMyocardium10aNephritis, Interstitial10aRifampin1 aLau G00aA fatal case of drug-induced multi-organ damage in a patient with Hansen's disease: dapsone syndrome or rifampicin toxicity?  a109-150 v733 a<p>An elderly patient with borderline tuberculoid Hansen's disease (leprosy) developed the diaminodiphenylsulphone syndrome after approximately 8 weeks of multi-drug therapy comprising dapsone and rifampicin. Postmortem histological examination, following autopsy, demonstrated features consistent with drug-induced hepatitis, tubulo-interstitial nephritis and myocarditis. Although these could have been engendered by dapsone toxicity, it was thought that a concommitant adverse reaction to rifampicin, which is known to be hepatotoxic, nephrotoxic and possibly capable of predisposing to the dapsone syndrome, could not be excluded.</p>  a0379-0738