01327nas a2200265   4500000000100000008004100001260001300042653001200055653002600067653001600093653002200109653001200131653000900143653002500152653001300177653001700190100001500207700001700222700001500239245012800254300001100382490000800393520064600401022001401047       1976                            d  c1976 Apr10aAnimals10aAntibodies, Bacterial10aClofazimine10aImmunosuppression10aleprosy10aMice10aMycobacterium leprae10aRifampin10aTime Factors1 aHolmes I B1 aBanerjee D K1 aHilson G R00aEffect of rifampin, clofazimine, and B1912 on the viability of Mycobacterium leprae in established mouse footpad infection.  a637-410 v1513 a<p>Continuous dietary administration of rifampin to mice with an established Mycobacterium leprae footpad infection reduced the bacillary solid ratio, with an estimated survival half-life of 5-6 days. In rifampin-treated immunosuppressed animals the survival half-life of solid bacilli, in the absence of host immunity, was 12-13 days. Clofazimine and B1912 produced a significant effect on solid ratio only after a lag period of apparently 100 days. The rate of action was considerably slower than that of rifampin. Intermittent (once monthly) administration of both drugs produced effects similar to those of continuous administration.</p>  a0037-9727