02087nas a2200337   4500000000100000008004100001260001300042653001200055653002000067653002700087653002700114653001200141653002500153100001500178700000900193700001500202700001500217700001300232700001800245700001300263700001800276700001600294700001500310245013000325856005900455300001100514490000700525050003200532520117100564022001401735       1995                            d  c1995 Jun10aAnimals10aCercocebus atys10aDisease Models, Animal10aDisease Susceptibility10aleprosy10aLongitudinal studies1 aGormus B J1 aXu K1 aBaskin G B1 aMartin L N1 aBohm R P1 aBlanchard J L1 aMack P A1 aRatterree M S1 aMcClure H M1 aMeyers W M00aExperimental leprosy in monkeys. I. Sooty mangabey monkeys: transmission, susceptibility, clinical and pathological findings.  uhttp://leprev.ilsl.br/pdfs/1995/v66n2/pdf/v66n2a02.pdf  a96-1040 v66  aInfolep Library - available3 a<p>A total of 31 sooty mangabey monkeys (SMM) (Cercocebus torquatus atys) inoculated by various routes with differing numbers of SMM-origin Mycobacterium leprae (ML) and 4 SMM inoculated with human-origin ML were observed for 4-12 years. SMM-origin ML was more pathogenic in SMM than human-origin ML. The spectrum of disease ranged from indeterminate to borderline and lepromatous in different animals. Some animals developed pure neural leprosy. Erythema nodosum leprosum (SNL) was also observed. Combined intravenous/intracutaneous (IV/IC) routes of inoculation more effectively induced advancing, disseminated lepromatous forms of leprosy; IV or IC routes alone were less effective at comparable doses. Total IV/IC doses of SMM-origin ML equal to or greater than 5 x 10(8), with morphologic indices (MIs) ranging from 5 to 10%, produced advancing, disseminated LL leprosy in 92% of SMM. Lower IV/IC doses and inoculations by a single IV or IC route produced fewer leprosy infections and more spontaneous regressions. As a species, captive SMM are highly susceptible to experimental leprosy and provide an excellent model for the longitudinal study of leprosy.</p>  a0305-7518