01877nas a2200325   4500000000100000008004100001260001300042653001200055653001300067653001900080653001800099653000900117653001500126653002200141653001900163653000900182653001700191653001000208653001800218653002400236100001500260700001000275700001300285245005100298856004100349300001000390490000700400520113000407022001401537       1999                            d  c1999 Jun10aAnimals10aCollagen10aForeign Bodies10aMagnoliopsida10aMale10aPlant Oils10aPlants, Medicinal10aPolypropylenes10aRats10aRats, Wistar10aTrees10aWound Healing10aWounds, Penetrating1 aOommen S T1 aRao M1 aRaju C V00aEffect of oil of hydnocarpus on wound healing.  uhttp://ila.ilsl.br/pdfs/v67n2a06.pdf  a154-80 v673 a<p>Oil of hydnocarpus has been replaced by other chemotherapeutic agents which have a better mycobactericidal effect. However, none of the currently used antileprosy drugs has been reported to have a positive effect in wound healing. Anecdotal reports claim that leprosy patients who have taken capsules containing oil of hydnocarpus orally have shown more rapid wound healing than those not receiving it. In view of these reports, a pilot experimental study was undertaken to determine the effect of the oil of hydnocarpus in wounds experimentally inflicted on male Wistar rats. The wound-healing effect of oil of hydnocarpus was studied with reference to collagenation and the strength of the scar tissue. The drug-treated group showed a significant increase in body weight and strength of scar tissue in the incision model and, also, increased strength of the collagen tissue and hydroxyproline content in the dead space model. The results of this pilot study indicate that the oil of hydnocarpus, which also has antileprotic activity, could be a useful adjunct in the healing of wounds and ulcers in leprosy patients.</p>  a0148-916X