01834nas a2200361   4500000000100000008004100001260001300042653001200055653002600067653001900093653001200112653003000124653001100154653002100165653001200186653000900198653002400207653001600231653001500247653001300262100001500275700001000290700001200300700001400312700001400326700001500340245013000355856004100485300001100526490000700537520091400544022001401458       1995                            d  c1995 Jun10aAnimals10aAnti-Infective Agents10aClarithromycin10aDapsone10aDrug Therapy, Combination10aFemale10aFluoroquinolones10aleprosy10aMice10aMice, Inbred BALB C10aMinocycline10aQuinolones10aRifampin1 aGelber R H1 aSiu P1 aTsang M1 aRichard V1 aChehl S K1 aMurray L P00aActivity of combinations of dapsone, rifampin, minocycline, clarithromycin, and sparfloxacin against M. leprae-infected mice.  uhttp://ila.ilsl.br/pdfs/v63n2a08.pdf  a259-640 v633 a<p>In these studies we evaluated the activity of low levels of five antimicrobials against Mycobacterium leprae-infected mice when administered singly and in all possible two- and three-drug combinations. Antibiotics studied were: dapsone (D) 0.0001% in the diet, rifampin (R) 20 mg/kg by gavage once monthly, minocycline (M) 0.004% in the diet, clarithromycin (C) 0.001% in the diet, and sparfloxacin (S) 5 mg/kg by gavage five times weekly. Singly each agent was found bacteriostatic (D + R) or partially bactericidal (M, C, and S) but not fully bactericidal. All 10 two-drug regimens were found at least bacteriostatic, 2 being "partially bactericidal" and 4 being "fully bactericidal." Of the 10 three-drug regimens, 9 were found "fully bactericidal" and the other "partially bactericidal." We conclude that combinations of antibiotics active against M. leprae are generally additive in combination.</p>
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