01129nas a2200241   4500000000100000008004100001260001300042653002300055653001400078653001100092653002300103653001200126653001600138653002500154653002500179100001500204245004300219300000900262490000700271050001500278520058000293022001400873       1995                            d  c1995 Jul10aAntibody Formation10aCytokines10aHumans10aImmunity, Cellular10aleprosy10aMacrophages10aMycobacterium leprae10aT-Lymphocyte Subsets1 aModlin R L00aCytokine responses in leprosy lesions.  a85-80 v64  aMODLIN19953 a<p>The clinical spectrum of leprosy reflects the diverse nature of human immune responses to Mycobacterium leprae. The clinical presentations correlate with the level of cell-mediated immunity against M. leprae. Cell-mediated immunity, as assessed by the Mitsuda reaction, is positive in tuberculoid patients and negative in lepromatous patients. In contrast, humoral immunity, as assessed by anti-M. leprae antibodies is greatest in lepromatous patients. The inverse correlation between cell-mediated immunity can be explained on the basis of the local cytokine pattern.</p>  a0386-3980