01606nas a2200361   4500000000100000008004100001260001600042653001200058653002900070653003100099653002700130653002100157653002300178653001200201653002800213653001300241653002500254100001000279700001500289700001300304700001200317700001200329700001200341700001600353700001600369700001800385245011700403856007800520300001000598490000800608520061400616022001401230       1999                            d  c1999 Aug 1510aDapsone10aDihydropteroate Synthase10aDrug Resistance, Microbial10aFolic Acid Antagonists10aGenes, Bacterial10aLeprostatic Agents10aleprosy10aMolecular Sequence Data10aMutation10aMycobacterium leprae1 aKai M1 aMatsuoka M1 aNakata N1 aMaeda S1 aGidoh M1 aMaeda Y1 aHashimoto K1 aKobayashi K1 aKashiwabara Y00aDiaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene.  uhttp://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.1999.tb13737.x/pdf  a231-50 v1773 a<p>The nucleotide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions.</p>  a0378-1097