01730nas a2200325   4500000000100000008004100001260001300042653002700055653001200082653002600094653002900120653001900149653003000168653001500198653001700213653001100230653002300241653001200264653001600276653003900292653003300331653000900364653001800373100001200391245006600403300000900469490000700478520090500485022001401390       1999                            d  c1999 Jul10aAdjuvants, Immunologic10aAnimals10aAnti-Bacterial Agents10aAnti-Inflammatory Agents10aClarithromycin10aDrug Therapy, Combination10aFosfomycin10aFusidic Acid10aHumans10aLeprostatic Agents10aleprosy10aMinocycline10aPeripheral Nervous System Diseases10aProtein Synthesis Inhibitors10aRats10aRoxithromycin1 aGidoh M00a[The control leprous peripheral neuropathy and chemotherapy].  a83-60 v683 a<p>Clarithromycin(CAM), Roxithromycin(RXM), Minocycline(MINO) and Fosfomycin(FOM) has anti-inflammatory action and immunomodulatory activity, while the anti-mycobacterium leprae activity is shown. CAM and RXM suppress the rat carrageenin edema, and MINO suppresses the rat adjvant arthritis. There is the immunosuppression on adrenocorticosteroid while the inflammatory cytokine is suppressed. CAM, MINO, FOM suppresses the inflammatory cytokine, while it has the immunomodulatory activity. Fusidic acid(FA) suppresses the inflammatory cytokine with the action of being similar to cyclosporin A, and it has the immunomodulatory activity. New macrolides derivatives, CAM and RXM showed the inflammatory regulation, and MINO showed the anti-inflammatory activity with FA. The combination chemotherapy can be enforced, while peripheral neuropathy is prevented by the control of the leprosy reaction.</p>  a1342-3681