02149nas a2200469   4500000000100000008004100001260001600042653002500058653002900083653001700112653001800129653003000147653002600177653001400203653001100217653002100228653001800249653001200267653002400279653002600303653002800329653002500357653002600382653004300408653002400451653002900475100001600504700001700520700001700537700001600554700001900570700001400589700001400603700001600617700001700633700001600650245007200666300001100738490000800749520090800757022001401665       1995                            d  c1995 Jul 1410aAntigen Presentation10aAntigen-Presenting Cells10aAntigens, CD10aAntigens, CD110aCarbohydrate Conformation10aCarbohydrate Sequence10aCell Line10aHumans10aInterferon-gamma10aInterleukin-410aleprosy10aLipopolysaccharides10aLymphocyte Activation10aMolecular Sequence Data10aMycobacterium leprae10aPhosphatidylinositols10aReceptors, Antigen, T-Cell, alpha-beta10aSpecies Specificity10aT-Lymphocytes, Cytotoxic1 aSieling P A1 aChatterjee D1 aPorcelli S A1 aPrigozy T I1 aMazzaccaro R J1 aSoriano T1 aBloom B R1 aBrenner M B1 aKronenberg M1 aBrennan P J00aCD1-restricted T cell recognition of microbial lipoglycan antigens.  a227-300 v2693 a<p>It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.</p>  a0036-8075