01589nas a2200277   4500000000100000008004100001260000900042653001900051653001400070653003500084653002300119653001100142653002800153653001200181653001600193653002000209653000900229653002800238100002300266700001500289245009800304300000900402490000700411520087900418022001401297       1980                            d  c198010aAcetylesterase10aEsterases10aGlucosephosphate Dehydrogenase10aHistocytochemistry10aHumans10aL-Lactate Dehydrogenase10aleprosy10aMacrophages10aOxidoreductases10aSkin10aSuccinate Dehydrogenase1 aVishnevetskiĭ F E1 aOsipov A A00a[Photometric studies of the activity of dehydrogenases and nonspecific esterases in leprosy].  a22-80 v423 a<p>The enzymatic activity of dehydrogenases and nonspecific esterases in skin affections in leprosy and their dynamics under the effect of treatment were investigated photometrically. It has been found that pentosophosphate pathway oxidation was mostly pronounced in microbe-containing macrophages of the infiltrate in untreated patients with the lepromatous type of leprosy and less according to the Krebs cycle and glycolysis. The intensity of oxidative processes is reduced under the influence of treatment, mainly, due to considerable inhibition of glycose-6-phosphatdehydrogenase. The activity of nonspecific esterases before the treatment is high in leprosy macrophages and low in the epidermis (as compared with the norm). Under the effect of antileprosy therapy the esterase content in the epidermis is restored and in the macrophages is decreased significantly.</p>  a0004-1955