01184nas a2200313   4500000000100000008004100001260001300042653001000055653001600065653001200081653002200093653003000115653001100145653001400156653001200170653000900182653001600191653001300207100001700220700001800237700001100255700001600266245003200282300001100314490000700325050003200332520049200364022001400856       1980                            d  c1980 Apr10aAdult10aClofazimine10aDapsone10aDrug Interactions10aDrug Therapy, Combination10aHumans10aIsoniazid10aleprosy10aMale10aMiddle Aged10aRifampin1 aVenkatesan K1 aBharadwaj V P1 aRamu G1 aDesikan K V00aStudy on drug interactions.  a229-350 v52  aInfolep Library - available3 a<p>Studies on the interactions of the drugs used in combination therapy of leprosy were attempted at this Institute. INH supplementation with clofazimine, therapy appeared to lower the skin levels of clofazimine, raising the plasma and urinary content of clofazimine. Concurrent administration of clofazimine with DDS does not appear to exert any influence on the excretion of DDS. The plasma DDS lowering effect of Rifampicin does not vary between fast and slow acetylators for DDS.</p>  a0024-1024