01715nas a2200241   4500000000100000008004100001260001300042653002000055653002000075653001100095653001200106653001800118653001300136653001400149100001100163700001500174700001300189245013100202300001000333490000700343520110900350022001401459       1978                            d  c1978 Nov10aCorynebacterium10aCross Reactions10aHumans10aleprosy10aMycobacterium10aNocardia10aRibosomes1 aLaub R1 aDelville J1 aCocito C00aImmunological relatedness of ribosomes from mycobacteria, nocardiae and corynebacteria, and microorganisms in leprosy lesions.  a540-70 v223 a<p>Serological relatedness of ribosomes from microorganisms of the Mycobacterium, Nocardia, and Corynebacterium genera has been analyzed by the microplate immunodiffusion technique. Mycobacterium and Nocardia proved homogeneous and closely related taxa, whereas Corynebacterium was found to be a heterogeneous phylum connected by remote links to the others. The taxonomic position of "diphtheroid microorganisms" (non-acid-fast, gram-positive bacteria morphologically similar to corynebactria), which were found together with Mycobacterium leprae in human leprosy lesions, was also investigated. Ribosomes of diphtheroid bacteria strongly cross-reacted with antisera against several mycobacteria and nocardiae but not against corynebacteria. Moreover, ribosomes from independently isolated diphtheroid strains proved serologically related and yielded strong cross-reactions with antisera against M. leprae as well as with sera from leprosy patients. Hence, diphtheroid microorganisms represent a homogeneous group immunologically related to mycobacteria in general and more specifically to M. leprae.</p>  a0019-9567