02018nas a2200349   4500000000100000008004100001260001700042653001100059653001900070653002200089653001100111653001400122653001200136653002000148653002600168653003000194653001700224653001700241100001400258700001300272700001400285700002200299700001400321700001900335245009200354856004800446300001100494490000700505050001500512520112700527022001401654       1999                            d  c1999 Jul-Sep10aBrazil10aCohort Studies10aFollow-Up Studies10aHumans10aIncidence10aleprosy10aLogistic Models10aMultivariate Analysis10aResidence Characteristics10aRisk Factors10aTime Factors1 aMatos H J1 aDuppre N1 aAlvim M F1 aMachadoVieira L M1 aSarno E N1 aStruchiner C J00a[Leprosy epidemiology in a cohort of household contacts in Rio de Janeiro (1987-1991)].  uhttp://www.scielo.br/pdf/csp/v15n3/0492.pdf  a533-420 v15  aMATOS 19993 a<p>This study aimed to identify factors influencing the development of leprosy (Hansen's disease) in household contacts. A dynamic cohort was analyzed from 1987 to 1991 at the Hansen's Disease Department of the Oswaldo Cruz Foundation in Rio de Janeiro. The incidence rate was 0.01694 person-years of follow-up. Nevertheless, for subjects at the end of the first year of follow-up the incidence rate was 0.06385 (end of second year, 0.03299; end of third year, 0.02370; end of fourth year, 0.018622; and end of observation period, 0.01694). A stepwise multivariate logistic regression model was proposed to study the risk of developing leprosy, including co-prevalent cases, totaling 758 contacts. In the final model, the risk was associated with a negative Mitsuda skin test (OR = 3.093; CI 95% = 1.735-5.514), prior BCG vaccination (OR = 0.3802; CI 95% = 0.2151-0.66719), and multibacillary primary clinical form (OR = 2.547; CI 95% = 1.249-5.192). The results showed that both multibacillary leprosy and specific immune status are significant indicators for developing the disease in a cohort of household contacts.</p>  a0102-311X