02236nas a2200253   4500000000100000008004100001260001600042653002000058653001000078653001100088653001100099653000900110653004500119653002700164100001300191700001400204700001600218700001300234245003800247300001100285490000800296520166400304022001401968       1999                            d  c1999 Sep 1810aAfrica, Western10aChild10aFemale10aHumans10aMale10aMycobacterium Infections, Nontuberculous10aMycobacterium ulcerans1 aWerf T S1 aGraaf W T1 aTappero J W1 aAsiedu K00aMycobacterium ulcerans infection.  a1013-80 v3543 a<p>After tuberculosis and leprosy, Buruli-ulcer disease (caused by infection with Mycobacterium ulcerans) is the third most common mycobacterial disease in immunocompetent people. Countries in which the disease is endemic have been identified, predominantly in areas of tropical rain forest; the emergence of Buruli-ulcer disease in West African countries over the past decade has been dramatic. Current evidence suggests that the infection is transmitted through abraded skin or mild traumatic injuries after contact with contaminated water, soil, or vegetation; there is one unconfirmed preliminary report on possible transmission by insects. The clinical picture ranges from a painless nodule to large, undermined ulcerative lesions that heal spontaneously but slowly. Most patients are children. The disease is accompanied by remarkably few systemic symptoms, but occasionally secondary infections resulting in sepsis or tetanus cause severe systemic disease and death. Extensive scarring can lead to contractures of the limbs, blindness, and other adverse sequelae, which impose a substantial health and economic burden. Treatment is still primarily surgical, and includes excision, skin grafting, or both. Although BCG has a mild but significant protective effect, new vaccine developments directed at the toxins produced by M. ulcerans are warranted. In West Africa, affected populations are underprivileged, and the economic burden imposed by Buruli-ulcer disease is daunting. Combined efforts to improve treatment, prevention, control, and research strategies (overseen by the WHO and funded by international relief agencies) are urgently needed.</p>  a0140-6736