01625nas a2200265   4500000000100000008004100001260000900042653001000051653001100061653002100072653001700093653001200110653001600122653001200138653002200150100001100172700001500183700001500198700001600213245007700229300001000306490000700316520102200323022001401345       1981                            d  c198110aAdult10aHumans10aImmunity, Innate10aImmunization10aleprosy10aMiddle Aged10aTetanus10aTetanus Antitoxin1 aSaha K1 aSharma V K1 aSehgal V N1 aAgarwal S K00aNatural resistance against tetanus in patients with lepromatous leprosy.  a832-40 v753 a<p>Tetanus antitoxin levels in the sera of unimmunized lepromatous patients, often suffering from many ulcerations on their limbs due to physical and thermal trauma, but not developing clinical tetanus, were studied. Sera from 40 such patients with no history of immunization against tetanus, 35 unimmunized matched controls and 12 immunized controls were tested for the presence of tetanus antitoxin by the passive haemagglutination technique. 45% of patients, 17% of controls and all the immunized patients showed adequate serum antibody levels. Eight of the 22 leprosy patients, with no detectable antitoxin on their sera, were immunized with a single dose of tetanus toxoid and all showed sero-conversion four weeks later. 2-Mercaptoethanol (2ME) treatment of these sera showed both IgM and IgG classes of specific antibody in all groups but the level of mature antibody of IgC class was higher in the immunized group. Neutralization test further confirmed the presence of protective antibodies in these sera.</p>  a0035-9203