01266nas a2200241   4500000000100000008004100001260001300042653001100055653001100066653001800077653001200095653001000107653000900117100001800126700001800144700001500162245005100177300001000228490000700238050003200245520073300277022001401010       1981                            d  c1981 Jul10aFemale10aHumans10aKupffer Cells10aleprosy10aLiver10aMale1 aGharpuray S M1 aGharpuray M B1 aKelkar S S00aLiver lesions in reactional states in leprosy.  a413-60 v53  aInfolep Library - available3 a<p>Liver biopsy was done in 21 adult patients of leprosy in acute reaction. They included 10 of lepromatous leprosy, seven of tuberculoid leprosy and four of dimorphic leprosy. Except for a single case of tuberculoid leprosy all showed granulomatous lesions of varying sizes and frequency, in the liver. The lesions appeared to be unique for reaction and immunologically-based. The sequence of events appeared to be: (1) Immunologically-mediated alteration of Kupffer cells with adhesion of lymphocytes and polymorphounuclear leucocytes (2) Small granulomas of proliferating Kupffer cells, lymphocytes and polymorphs. (3) In some cases. formation of larger granulomas with breaking down of reticulin and liver cell necrosis.</p>  a0024-1024