01961nas a2200373   4500000000100000008004100001260001300042653001000055653001600065653002000081653001100101653001100112653001200123653000900135653002200144653001300166653001800179653001600197653001600213653002200229100001500251700001100266700001500277700001200292700002000304700001100324700001600335245008600351300001100437490000700448050003200455520108600487022001401573       1981                            d  c1981 Jul10aAdult10aAngiography10aBrachial Artery10aFemale10aHumans10aleprosy10aMale10aNeural Conduction10aNeuritis10aSpinal Nerves10aSural Nerve10aUlnar nerve10aVascular Diseases1 aChopra J S1 aKaur S1 aMurthy J M1 aKumar B1 aRadhakrishnan K1 aSuri S1 aSawhney B B00aVascular changes in leprosy and its role in the pathogenesis of leprous neuritis.  a443-530 v53  aInfolep Library - available3 a<p>The arteriographic pattern of left hand vessels was studied in 20 patients in leprosy by percutaneous brachial arteriography. Arteriographic abnormalities noted consisted of occlusion, narrowing, tortuosity, dilatation, irregularity and incomplete filling of the lumen by contrast medium. Such abnormal findings were seen in all the arteriograms studied and more than one vessel involvement was noted in over 50 percent cases. This study clearly demonstrated that arterial involvement in leprosy was frequent. No correlation was found between motor weakness and vascular abnormalities. There was no difference in arterial lesions between the patients with and without trophic changes. There was also no correlation between the severity of vascular changes and decline in motor nerve conduction. Degree of histopathological abnormalities in the sural nerve biopsy from these patients showed no features of micro angiopathic neuropathy. It is concluded that the observed vascular abnormalities do not contribute significantly in the genesis of neurological deficit in leprosy.</p>  a0024-1024