01701nas a2200277   4500000000100000008004100001260001300042653001200055653001300067653001500080653001400095653001100109653002100120653001700141653001200158653001800170653002300188653001600211100001700227700001800244245012000262300001100382490000800393520100800401022001401409       1978                            d  c1978 Jun10aAnimals10aAntigens10aEpithelium10aGranuloma10aHumans10aHypersensitivity10aNerve Tissue10aRabbits10aSkin Diseases10aSpinal Nerve Roots10aSural Nerve1 aCrawford C L1 aHardwicke P M00aUltrastructural features of epithelioid cell granuloma induced by intradermal injection of xenogeneic nerve tissue.  a107-130 v1253 a<p>Epithelioid cell granulomas were induced in rabbits previously sensitised with human sensory peripheral nerve extract by skin testing with homogenate of sural nerve. Ultrastructurally some of the cells contained in their cytoplasm abundant and dilated rough endoplasmic reticulum filled with a moderately dense product while the cytoplasm of other cells contained numerous membrane-bound vesicles. These cells show all the ultrastructural characteristics of epithelioid cells found in human granulomatous disease and in human states of granulomatous hypersensitivity. Thus we have developed an animal model which supports the concept of granulomatous hypersensitivity as a distinct entity in humans to be differentiated from foreign body and delayed-type hypersensitivity reactions. The model may also prove important in elucidating the pathogenesis of granuloma formation in non-lepromatous leprosy and other granulomatous disease and in defining the nature of the products of epithelioid cells.</p>  a0022-3417