01154nas a2200241   4500000000100000008004100001260001300042653001000055653001400065653001100079653001200090653001600102653000900118653002500127100001500152700001500167245005300182856004100235300001000276490000700286520060500293022001400898       1980                            d  c1980 Jun10aAdult10aGranuloma10aHumans10aleprosy10aMacrophages10aMale10aMicroscopy, Electron1 aRidley M J1 aRidley D S00aHistoid leprosy. An ultrastructural observation.  uhttp://ila.ilsl.br/pdfs/v48n2a04.pdf  a135-90 v483 a<p>A young active histoid nodule from an untreated patient with lepromatous leprosy was examined by electron microscopy. The only area where spindle-shaped cells predominated was near the pseudocapsule, and these cells were the only ones that were associated with the presence of collagen. The main mass of the granuloma was composed of young macrophages which showed evidence of a higher cell turnover rate than in ordinary lepromatous leprosy. Among the macrophages were plasmacytoid cells. Histoid lesions are thought to be essentially hyperactive, but the nature of the stimulus is unknown.</p>
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