01929nas a2200421   4500000000100000008004100001260000900042653002000051653001500071653001000086653000900096653001200105653002400117653001500141653001000156653001100166653001100177653002100188653001300209653001200222653002400234653002500258653002500283653000900308653000900317653001600326653002500342100002000367700001700387700001600404700001600420700001800436245015300454300001100607490000700618520086800625022001401493       1999                            d  c199910aActinomycetales10aAdolescent10aAdult10aAged10aAnimals10aAntigens, Bacterial10aArmadillos10aChild10aFemale10aHumans10aImmune Tolerance10aLepromin10aleprosy10aLeprosy, Borderline10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMale10aMice10aMiddle Aged10aMycobacterium leprae1 aChakrabarty A N1 aDastidar S G1 aChandra A K1 aMukherjee M1 aChaudhuri S K00aA comparative study on the Mitsuda type response to antigens of chemoautotrophic nocardioform bacteria and to standard lepromin in leprosy patients.  a105-120 v113 a<p>Anergy, or contrarily, Mitsuda-type responses towards 4 chemoautotrophic nocardioform antigens (CAN-Ags) and a control standard lepromin were tested in 73 LL, TT and borderline cases of leprosy. The antigens injected per patient varied from a maximum of 5 to a minimum of 2. Complete anergy to CAN-Ags was seen in 92/92 instances tested on 24 LL cases. The anergy was weakly modified or unmodified in 3 other LL cases which had been vaccinated before. Concurrent studies with the same antigens tested on 33 TT cases showed clear-cut, dose-dependent, Mitsuda-type late responses in 80/81 instances. The CAN bacteria, therefore, despite their origin from different unrelated leprous human, mouse footpad (MFP) and armadillo tissues, appeared to be identical with each other and also probably related to the leprosy bacillus, on the basis of these parameters.</p>  a0001-5938