02154nas a2200361   4500000000100000008004100001260001300042653001000055653002000065653002400085653001600109653001100125653001100136653003000147653001300177653001200190653002000202653001500222653000900237653001700246653001700263100002100280700002200301700002100323700002000344700001300364245012700377856004100504300001100545490000700556520121500563022001401778       1980                            d  c1980 Jun10aAdult10aCells, Cultured10aChemotactic Factors10aEndocytosis10aFemale10aHumans10aImmune Adherence Reaction10aLepromin10aleprosy10aLeukocyte Count10aLeukocytes10aMale10aPhagocytosis10aTime Factors1 aRojas-Espinosa O1 aAponte-Vázquez J1 aGonzález Cruz O1 aEstrada-Parra S1 aOrtíz Y00aPhagocytosis in leprosy. III. Defective adhesive and endocytic abilities of circulating leukocytes in lepromatous leprosy.  uhttp://ila.ilsl.br/pdfs/v48n2a07.pdf  a159-660 v483 a<p>Two aspects of the phagocytic process in normal and lepromatous polymorphonuclears (PMN) and monocytes (MN) were studied. These aspects were endocytosis and adherence to surfaces. These 2 phenomena are closely related to each other and to the whole phagocytic process as they depend on membrane activity. It was found that both lepromatous phagocytes (PMN and MN) show, on the average, a depressed ability to endocytose opsonized Mycobacterium lepraemurium when compared to normal phagocytes. This impairment, however, does not seem to be related to intrinsic defects in the phagocytic cells themselves but to the presence in lepromatous serum of factors that interfere with the endocytic function. This conclusion was drawn from the fact that lepromatous serum causes a similar diminution in the endocytic ability of normal phagocytes. On the other hand, lepromatous plasma but not indeterminate leprosy nor normal plasmas interfere with the capacity of PMN leukocytes to adhere in vitro to plastic surfaces. These impairments in the phagocytic function might help to better understand the depressed overall inflammatory responses observed in vivo in lepromatous patients with a long-lasting disease.</p>
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