01251nas a2200277   4500000000100000008004100001260001300042653002000055653001100075653002300086653001200109653001200121653002600133653001600159653002500175100001600200700001400216700001800230700001400248245017300262856004100435300001000476490000700486520046600493022001400959       1980                            d  c1980 Jun10aCells, Cultured10aHumans10aImmunity, Cellular10aleprosy10aLeucine10aLymphocyte Activation10aMacrophages10aProtein Biosynthesis1 aSalgame P R1 aBirdi T J1 aMahadevan P R1 aAntia N H00aRole of macrophages in defective cell mediated immunity in lepromatous leprosy. I. Factor(s) from macrophages affecting protein synthesis and lymphocyte transformation.  uhttp://ila.ilsl.br/pdfs/v48n2a09.pdf  a172-70 v483 a<p>Macrophages from lepromatous leprosy patients specifically show reduced protein synthesis in the presence of M. leprae. They also produce, as a result of interaction with M. leprae, factor(s) that reduce protein synthesis in normal macrophages as well as block lymphocyte transformation in normal leukocyte cultures in the presence of M. leprae as the antigen. These observations implicate a defective macrophage system in lepromatous leprosy patients.</p>
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