01558nas a2200277   4500000000100000008004100001260001300042653001200055653000800067653001100075653001200086653001000098653000900108653001600117653000900133653002000142100001800162700001500180700001500195245004900210856004100259300001100300490000700311520094800318022001401266       1980                            d  c1980 Dec10aAnimals10aEye10aKidney10aleprosy10aLiver10aLung10aLymph Nodes10aMale10aPan troglodytes1 aLeininger J R1 aDonham K J1 aMeyers W M00aLeprosy in a chimpanzee. Postmortem lesions.  uhttp://ila.ilsl.br/pdfs/v48n4a07.pdf  a414-210 v483 a<p>A young (5-7 year old) male chimpanzee died 33 months after the first clinical manifestations of a naturally acquired disease that was similar to disseminated leprosy in man. At autopsy there were diffuse or multifocal histiocytic infiltrations of the skin, nasal mucosa, pharynx, lung interstitium, liver, spleen, sclera, testicles, adrenal glands, and peripheral lymph nodes. Major nerves of the forearms had extensive fibrosis. There were large numbers of acid-fast bacilli (AFB), many occurring as globi, in histiocytes in most affected tissues including nerves. The histopathologic features of the disease and the microbiologic and antigenic properties of the AFB in the tissues indicate that Mycobacterium leprae or an organism indistinguishable from it was the causative agent. This and other cases of leprosy in nonhuman primates indicate that studies of the development of nonhuman primate models for leprosy may be worthwhile.</p>  a0148-916X