01694nas a2200289   4500000000100000008004100001260001300042653002000055653001300075653001100088653001200099653001700111653001400128653001700142100001500159700001500174700001300189700001500202700001300217700001300230245008300243856004100326300000900367490000700376520100700383022001401390       1981                            d  c1981 Mar10aBlood Platelets10aFructose10aHumans10aleprosy10aMucoproteins10aSerotonin10aSialic Acids1 aSzabados L1 aLaunay J M1 aMester M1 aCottenot F1 aPennec J1 aMester L00aLow serotonin uptake by platelets in leprosy and a new approach to prevent it.  uhttp://ila.ilsl.br/pdfs/v49n1a08.pdf  a42-80 v493 a<p>The plasma of leprosy patients contains high levels of mucoproteins which are deficient in sialic acid. However, due to the increased mucoprotein level, the total sialic acid content of leprous plasma, calculated on protein, is increased when compared with normal human plasma. The low serotonin uptake observed with isolated platelets is probably due to their low sialic acid content. The inability of normal human plasma to correct the diminished serotonin uptake by isolated leprous platelets is in favor of a definite structural change in leprous platelets, related to their low sialic acid content. In patients with active disease and in those with lepra reactions, leprous plasma itself can correct the diminished uptake of serotonin by the isolated platelets. In patients with subsided lepra reactions, the leprous plasma is much less effective. In severe cases, where serotonin uptake is decreased even in platelet rich plasma, desoxyfructo-serotonin increased the uptake of serotonin.</p>
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