02498nas a2200349   4500000000100000008004100001260001300042653001500055653001000070653000900080653001100089653001000100653001600110653001100126653001100137653001200148653000900160653001600169653000900185653002200194653001900216100001500235700001500250700001300265700001800278245013700296856004100433300001100474490000700485520164200492022001402134       1981                            d  c1981 Jun10aAdolescent10aAdult10aAged10aBiopsy10aChild10aClofazimine10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aSkin10aSkin Pigmentation10aUnited Kingdom1 aBrowne S G1 aHarman D J1 aWaudby H1 aMcDougall A C00aClofazimine (Lamprene, B663) in the treatment of lepromatous leprosy in the United Kingdom. A 12 year review of 31 cases, 1966-1978.  uhttp://ila.ilsl.br/pdfs/v49n2a03.pdf  a167-760 v493 a<p>This paper records the results of treatment with clofazimine of a group of 31 patients of mixed racial origin in the United Kingdom suffering from lepromatous or borderline-lepromatous leprosy. Progress was assessed by clinical and histopathological examination for periods up to 12 years after starting treatment. Although given mainly for dapsone resistance, either proven on mouse foot pad inoculation or strongly suspected on clinical grounds, clofazimine was also used in some patients for the suppression of reactions, notably those due to the formation of immune-complexes, the manifestations of which included erythema nodosum leprosum (ENL). Four patients, all of whom had taken clofazimine in relatively high dosage for many months, usually for ENL, complained about pigmentation. in the remaining patients, on doses of the order of 100 mg three times weekly, pigmentation was not a problem. None of the 31 patients suffered from gastro-intestinal symptoms or signs of any significance during the period of study. Many of the patients started taking dapsone in the 1940s; most had a long, complex, and unsatisfactory history of previous treatment with many drugs. This made assessment of response to clofazimine difficult in some cases. The general impression is that clofazimine has been outstandingly valuable both as regards treatment of the bacillary infection and the suppression of reaction. No patient relapsed during the period of study. The authors express the opinion that no other drug currently available for the treatment of leprosy could have achieved such good results in a comparable group of patients.</p>
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