02392nas a2200481 4500000000100000008004100001260001600042653001000058653002000068653004200088653001100130653001900141653001600160653001400176653001900190653001100209653001200220653002500232653000900257653001600266653001500282653003000297653001600327100001400343700001100357700001400368700001200382700002400394700001300418700001200431700001300443700001300456700001500469700002100484700002400505700001400529245016600543856010700709300001100816490000800827520106100835022001401896 2010 d c2010 Aug 15 10 aAdult 10 aAnti-HIV Agents 10 aAntiretroviral Therapy, Highly Active 10 aBrazil 10 aCohort Studies 10 aComorbidity 10 aGranuloma 10 aHIV Infections 10 aHumans 10 aleprosy 10 aLongitudinal studies 10 aMale 10 aMiddle Aged 10 aPrevalence 10 aSeverity of Illness Index 10 aYoung Adult 1 aTalhari C 1 aMira M 1 aMassone C 1 aBraga A 1 aChrusciak-Talhari A 1 aSantos M 1 aOrsi AT 1 aMatsuo C 1 aRabelo R 1 aNogueira L 1 aLima Ferreira LC 1 aRibeiro-Rodrigues R 1 aTalhari S 00 aLeprosy and HIV coinfection: a clinical, pathological, immunological, and therapeutic study of a cohort from a Brazilian referral center for infectious diseases. uhttp://jid.oxfordjournals.org/content/202/3/345.full.pdf+html?sid=bdeaafc9-0d5f-4023-a403-d5a466936be1 a345-54 0 v202 3 aBACKGROUND: Although awareness of the relevance of leprosy and human immunodeficiency virus (HIV) coinfection is increasing worldwide, several aspects of this co-occurrence are not fully understood.
METHODS: We describe clinical, pathological, immunological, and therapeutic long-term follow-up of a cohort of 25 individuals with leprosy and HIV infection from Manaus, Amazonas.
RESULTS: Careful description of our cohort indicates a higher prevalence of leprosy in an HIV-positive population than that in the general population. We also observed upgrading shifting of leprosy clinical forms after initiation of highly active antiretroviral therapy and multidrug therapy and an impact of HIV infection on leprosy granuloma formation, among other features.
CONCLUSION: Taken together, these new insights allow the proposition of a classification system that includes (1) leprosy and HIV true coinfection, (2) opportunistic leprosy disease, and (3) leprosy related to highly active antiretroviral therapy.
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