01373nas a2200265   4500000000100000008004100001260001700042653001000059653002000069653001100089653001100100653001200111653000900123653000900132653001400141100002300155700001900178700001900197700002300216245006600239300001100305490000800316520076900324022001401093       1982                            d  c1982 Nov-Dec10aAdult10aDrug Evaluation10aFemale10aHumans10aleprosy10aMale10aMali10aSerotonin1 aMester de Parajd L1 aBalakrishnan S1 aSaint-André P1 aMester de Parajd M00aDeoxyfructo-serotonin: a new drug with anti-leprosy activity.  a427-320 v1333 a<p>In the mouse foot pas, deoxyfructo-serotonin (DFS) shows a definite inhibitory effect on the multiplication of M. leprae in Dapsone-sensitive as well as Dapsone-resistant cases. In clinical trials, based on 7 cases treated with DFS for an average period of 6 months, the beneficial effects of DFS are observed after a few weeks of treatment in BB cases, and after a few months in LL cases. In addition to clear improvements in the appearance of the skin (regression and healing of nodules, almost complete disappearance of infiltration, etc) one observes in the majority of cases a rapid improvement in the bacteriological and morphological indexes, the latter falling to 0%. In the course of these studies, no single suggestion of intolerance was detected.</p>  a0300-5410