01772nas a2200253   4500000000100000008004100001260001300042653002600055653002100081653001100102653001200113653001600125653002600141653002400167100001100191700001500202700001300217700001400230245010500244300001100349490000700360520113700367022001401504       1978                            d  c1978 Sep10aChemotaxis, Leukocyte10aErythema Nodosum10aHumans10aleprosy10aNeutrophils10aNitroblue Tetrazolium10aOxidation-Reduction1 aSher R1 aAnderson R1 aGlover A1 aWadee A A00aPolymorphonuclear cell function in the various polar types of leprosy and erythema nodosum leprosum.  a959-650 v213 a<p>Polymorphonuclear leukocyte motility, both in vivo and in vitro, and reduction of Nitro Blue Tetrazolium was studied in tuberculoid and lepromatous leprosy patients and a group of lepromatous patients with erythema nodosum leprosum (ENL). A profound defect in random migration, chemotaxis, and chemokinesis was found in lepromatous patients with and without complicating ENL, and marked depletion of skin window migration confirmed these in vitro findings. Tuberculoid patients exhibited a mild defect in polymorphonuclear leukocyte motility. Serum inhibitors of normal polymorphonuclear leukocyte chemotaxis were found in all types of leprosy, but sera from lepromatous and ENL patients were most inhibitory. Resting levels of Nitro Blue Tetrazolium reduction were normal in all three groups. Reconstitution of polymorphonuclear leukocyte cells from normal and ENL patients with ENL serum, however, showed increased Nitro Blue Tetrazolium reduction well above the normal range, whereas reconstitution with normal, lepromatous, and tuberculoid sera failed to increase Nitro Blue Tetrazolium reduction above the normal values.</p>  a0019-9567