01448nas a2200253   4500000000100000008004100001260001300042653001200055653002700067653001600094653001200110653000900122653002100131653001700152653001800169100001100187700001500198245008900213300000900302490000700311050003200318520083000350022001401180       1982                            d  c1982 Jan10aAnimals10aDemyelinating Diseases10aGuinea Pigs10aleprosy10aMice10aMice, Inbred CBA10aNerve Fibers10aSciatic Nerve1 aBhat R1 aVaidya M C00aNerve damage in leprosy-a teased fibre study of sciatic nerves in experimental mice.  a33-90 v54  aInfolep Library - available3 a<p>The extent of nerve damage was assessed in the sciatic nerves of CBA/J mice with experimental leprosy by the teased single fibre preparations. Morphological changes in the fibres were observed upto 15 months of infection and compared with control animals of the same age groups. During 4 to 9 months period, the fibres showed paranodal enlargements, widening of the Schmidt-Lantermann incisures, paranodal and whole segmental demyelination. In addition, fragmentation of axons with the formation of myelin ovoids in the schwann tubes was also observed in animals with 9 to 15 months of infection. While segmental demyelination was predominant early in infection, axonal degeneration was more evident in advanced infection. These findings may possibly, explain the underlying mechanism of nerve damage in human leprosy.</p>  a0024-1024