02587nas a2200397   4500000000100000008004100001260001300042653002300055653001600078653001200094653002400106653003000130653001100160653001800171653001300189653002300202653001200225653002500237653001300262653002400275653001500299653002600314100001300340700001200353700001400365700001600379700001100395700001600406700001100422245026000433856004100693300001100734490000700745520142300752022001402175       1999                            d  c1999 Sep10aBacterial Vaccines10aClofazimine10aDapsone10aDouble-Blind Method10aDrug Therapy, Combination10aHumans10aImmunotherapy10aLepromin10aLeprostatic Agents10aleprosy10aMycobacterium leprae10aRifampin10aSingle-Blind Method10aSkin Tests10aVaccines, Inactivated1 aSharma P1 aKar H K1 aMisra R S1 aMukherjee A1 aKaur H1 aMukherjee R1 aRani R00aInduction of lepromin positivity following immuno-chemotherapy with Mycobacterium w vaccine and multidrug therapy and its impact on bacteriological clearance in multibacillary leprosy: report on a hospital-based clinical trial with the candidate antilepro  uhttp://ila.ilsl.br/pdfs/v67n3a05.pdf  a259-690 v673 a<p>A vaccine based on autoclaved Mycobacterium w was administered, in addition to standard multidrug therapy (MDT), to 157 bacteriologically positive, lepromin-negative, multibacillary (LL, BL and BB) leprosy patients. The vaccinees were supported by a well-matched control group of 147 patients with similar type of disease who received a placebo injection in addition to MDT. The MDT was given for a minimum period of 2 years and continued until skin-smear negativity, while the vaccine was given at 3-month intervals up to a maximum of 8 doses. The lepromin response evaluated in terms of percentage of subjects converting to positivity status, measurement in millimeters, and duration of lepromin positivity sustained, reflected a statistically significant better outcome in the vaccine group patients (especially LL and BL leprosy) in comparison to those in the placebo group. The data indicate that lepromin-positivity status seems to have an impact on accelerating the bacteriological clearance, as is evident by the statistically significant accelerated decline in the BI of those patients who converted to lepromin positivity as compared to those remaining lepromin negative throughout therapy and post-therapy follow up. To conclude, the addition of the Mycobacterium w vaccine to standard MDT induces a lepromin response of a statistically significant higher magnitude than that observed with MDT alone.</p>  a0148-916X