00961nas a2200229   4500000000100000008004100001260001300042653001000055653002600065653001700091653001100108653001200119653000900131100001600140700001800156700001300174245006300187300001100250490000800261520044800269022001400717       1982                            d  c1982 Nov10aAdult10aChemotaxis, Leukocyte10aGriseofulvin10aHumans10aleprosy10aMale1 aShulman D G1 aWilkinson R D1 aNguyen N00aLeprosy downgrading reaction associated with griseofulvin.  a909-120 v1183 a<p>A dramatic alteration from clinically subpolar tuberculoid leprosy toward subpolar lepromatous leprosy was observed during griseofulvin therapy in a 29-year-old man, despite apparently normal cell-mediated immunity. To our knowledge, this is the first reported case of a downgrading reaction associated with griseofulvin. It is possible that this reaction was due to inhibition of polymorphonuclear leukocyte chemotaxis by griseofulvin.</p>  a0003-987X