01260nas a2200301   4500000000100000008004100001260000900042653001200051653001200063653002200075653003000097653001400127653002300141653001200164653000900176653001800185653002500203653001800228100001500246700001500261700001400276700002000290245012900310300001100439490000700450520048700457022001400944       1981                            d  c198110aAnimals10aDapsone10aDrug Interactions10aDrug Therapy, Combination10aIsoniazid10aIsonicotinic Acids10aleprosy10aMice10aMycobacterium10aMycobacterium leprae10aProthionamide1 aPattyn S R1 aPortaels F1 aVan Loo G1 aVan den Breen L00aActivity of the combination of isoniazid, protionamide and dapsone against Mycobacterium leprae and some other mycobacteria.  a2155-70 v313 a<p>No additive effect was found at the addition of isoniazid to either dapsone or protionamide against M. leprae and against highly dapsone-sensitive in vitro growing Mycobacterium sp. strains. It is concluded that the indication of the administration of isoniazid in leprosy is extremely limited and could only be envisaged as a companion drug in combined therapy of dapsone-resistant multibacillary leprosy in light-skinned people, when aminoglycosides cannot be administered.</p>  a0004-4172