01352nas a2200253   4500000000100000008004100001260001300042653002400055653001100079653003000090653001700120653001200137653002400149653002500173653001500198100001400213700001300227700001300240245012700253300001100380490000700391520068600398022001401084       1981                            d  c1981 Jun10aAntigens, Bacterial10aHumans10aHypersensitivity, Delayed10aImmunization10aleprosy10aMycobacterium bovis10aMycobacterium leprae10aSkin Tests1 aSmelt A H1 aRees R H1 aLiew F Y00aFailure to induce delayed-type hypersensitivity to Mycobacterium leprae in long-term treated lepromatous leprosy patients.  a507-110 v443 a<p>Lepromatous leprosy (LL) patients whose bacillary load has decreased to almost undetectable levels by long-term chemotherapy failed to develop delayed-type hypersensitivity (DTH) to Mycobacterium leprae antigen following immunization with killed armadillo-derived M. leprae. When these LL patients were immunization with killed armadillo-derived M. leprae. When these LL patients were immunized with killed M. leprae in a mixture with live BCG, only DTH to purified protein derivative (PPD) was induced. These results are further evidence that immunological unresponsiveness to the leprosy antigen of patients with lepromatous leprosy is antigen-specific and non-reversible.</p>  a0009-9104