01422nas a2200313   4500000000100000008004100001260001300042653002600055653001100081653001600092653001100108653002100119653002100140653001200161653002800173653002500201653001400226653002100240100001300261700001300274700001500287700001500302245015000317300001100467490000700478050001600485520059300501022001401094       1981                            d  c1981 Oct10aAntibodies, Bacterial10aFemale10aFetal Blood10aHumans10aImmunoglobulin A10aImmunoglobulin M10aleprosy10aMaternal-Fetal Exchange10aMycobacterium leprae10aPregnancy10aRadioimmunoassay1 aMelsom R1 aHarboe M1 aDuncan M E1 aBergsvik H00aIgA and IgM antibodies against Mycobacterium leprae in cord sera and in patients with leprosy: an indicator of intrauterine infection in leprosy.  a343-520 v14  aMELSOM 19813 a<p>A solid-phase radioimmunoassay was developed for demonstration and quantification of IgA and IgM anti-M. leprae antibodies. IgA and IgM anti-M. leprae antibodies were demonstrated in a lepromatous serum pool, in various amounts in individual patients with lepromatous leprosy, and in lower concentration in tuberculoid leprosy and non-leprosy controls. IgA and IgM anti-M. leprae antibodies were demonstrated in cord sera from babies of mothers with leprosy. The reliability of fetal IgA and IgM antibody synthesis as an indicator of intrauterine infection in leprosy is discussed.</p>  a0300-9475