01651nas a2200325   4500000000100000008004100001260000900042653001200051653002400063653001100087653002100098653002100119653001300140653003700153653001800190653001200208653001600220653001600236653001800252653002900270653001600299653001500315653001600330100001700346245004800363300001100411490000600422520088300428022001401311       1982                            d  c198210aAnimals10aAntigens, Bacterial10aHumans10aHypersensitivity10aImmune Tolerance10aImmunity10aImmunologic Deficiency Syndromes10aImmunotherapy10aleprosy10aLymphocytes10aMacrophages10aMycobacterium10aMycobacterium Infections10aNeutrophils10aTuberculin10aVaccination1 aChaparas S D00aThe immunology of mycobacterial infections.  a139-970 v93 a<p>Mycobacteria are endowed with substances that profoundly affect the immune system. Leprosy and tuberculosis exemplify broad spectra of useful and detrimental immune responses of mycobacterial infections that range from intense potentiation to severe specific adn nonspecific suppression of humoral and cellular immune elements. The cellular hypersensitivity induced by mycobacteria serves as a classical model for the analysis of specific and nonspecific immune mechanisms. Mycobacterial disease are prevalent worldwide and rank among the most important bacterial diseases. The kaleidoscope of immunologic events induced by injected mycobacteria and during infections will be reviewed from the standpoint of pathogenesis, pathology, in vitro and in vivo effects on cellular and humoral arms of the immune response, diagnosis, classification, potentiation and suppression.</p>  a1040-841X