00999nas a2200217   4500000000100000008004100001260001300042653001200055653003100067653001100098653001200109653002500121653000900146100001500155245005700170300001100227490000700238050003200245520049000277022001400767       1982                            d  c1982 Jan10aDapsone10aDrug Resistance, Microbial10aHumans10aleprosy10aMycobacterium leprae10aSkin1 aTaylor P M00aThe clinical diagnosis of dapsone resistant leprosy.  a117-220 v54  aInfolep Library - available3 a<p>For the early recognition of dapsone resistance, it is essential to regularly examine patients at risk for suspicious new lesions, backed by regular clinical treatment records including smear results. The earlier the recognition and starting on alternative treatment, the better is the response. However, it is not advisable to change treatment without attempting at least clinical confirmation, and endorsing the chart so that the problem is not missed on subsequent occasions.</p>  a0024-1024