01390nas a2200337   4500000000100000008004100001260001700042653001800059653001400077653001600091653001200107653001100119653001200130653002500142653002500167653001400192653001400206653001300220653000900233100001400242700001500256700001400271700001700285700001300302700001400315245012000329300001000449490000800459520057100467022001401038       1982                            d  c1982 Jul-Aug10aCell Membrane10aCell Wall10aClofazimine10aDapsone10aHumans10aleprosy10aMicroscopy, Electron10aMycobacterium leprae10aOrganoids10aRibosomes10aRifampin10aSkin1 aSilva M T1 aMacedo P M1 aCosta M H1 aGonçalves H1 aTorgal J1 aDavid H L00aUltrastructural alterations of mycobacterium leprae in skin biopsies of untreated and treated lepromatous patients.  a75-920 v1333 a<p>1. -- Mycobacterium leprae cells under a process of progressive disaggregation are present in the skin of both treated and untreated patients. 2. -- The ultrastructural alterations observed during the degenerative process seem to be qualitatively similar in treated and untreated patients. 3. -- The proportion of altered M. leprae cells increases during the treatment, mainly with rifampicin and rifampicin + clofazimine + diaminodiphenyl sulfone. 4. -- The cell wall of M. leprae is the last bacterial structure to disappear during the degenerative process.</p>  a0300-5410