01417nas a2200301   4500000000100000008004100001260001600042653001200058653002400070653002300094653002100117653001200138653000900150653002400159653001500183653002500198653001100223100001200234700001500246700001200261700001600273700001300289245009600302300001000398490000700408520068600415022001401101       1999                            d  c1999 Dec 1010aAnimals10aAntigens, Bacterial10aBacterial Vaccines10aInterferon-gamma10aleprosy10aMice10aMice, Inbred BALB C10aMice, Nude10aMycobacterium leprae10aSpleen1 aNaito M1 aMatsuoka M1 aOhara N1 aNomaguchi H1 aYamada T00aThe antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice.  a795-80 v183 a<p>The proteins in culture filtrate derived from Bacillus Calmette-Guérin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon gamma (IFNgamma) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection.</p>  a0264-410X