01953nas a2200325   4500000000100000008004100001260001300042653001100055653001900066653002000085653001300105653004100118653001100159653001200170653000900182653001200191653002500203653001400228100001400242700001400256700001500270700001400285700001700299700001300316245009900329300001200428490000700440520116600447022001401613       1980                            d  c1980 Oct10aFemale10aGene Frequency10aGenetic Markers10aHaploidy10aHistocompatibility Antigens Class II10aHumans10aleprosy10aMale10aMeiosis10aMycobacterium leprae10aPhenotype1 aVries R R1 aMehra N K1 aVaidya M C1 aGupte M D1 aMeera Khan P1 aRood J J00aHLA-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR types.  a294-3040 v163 a<p>In an attempt to confirm an HLA-linked effect on the course of Mycobacterium leprae infection observed in families from Surinam (South America), we conducted a similar family study in an endemic area in India. We observed a significant (P less than .05) excess of identical HLA-GLO haplotypes only from healthy parents among siblings affected with tuberculoid leprosy. Compared with healthy controls, unrelated patients with tuberculoid leprosy (n = 15) showed a significant heterogeneity at the HLA-DR locus (P less than .05). This heterogeneity was caused by an increased frequency of HLA-DRw2 (.93 versus .53, P less than .05), particularly of DRw2 homozygotes (.53 versus .11, P less than .005), and a decreased frequency of HLA-DRw6 (.07 versus .58, P less than .005). We observed a significant (P = .03) preferential segregation of DRw2 from DRw2 heterozygous parents not affected with tuberculoid leprosy to children with the tuberculoid type of the disease. These data confirm an HLA-linked control of susceptibility to tuberculoid leprosy only, and suggest a recessive inheritance of this trait for which HLA-Drw2 appears to be a genetic marker.</p>  a0001-2815