01609nas a2200349   4500000000100000008004100001260000900042653001200051653001500063653002900078653002500107653001700132653001100149653003500160653001100195653002100206653002100227653002100248653001200269653001000281100001100291700001500302700001600317700001300333700001300346700001400359245007100373300001000444490000700454520078400461022001401245       1981                            d  c198110aAnimals10aAntibodies10aAntigen-Antibody Complex10aBinding, Competitive10aCardiolipins10aCattle10aFluorescent Antibody Technique10aHumans10aImmunoglobulin A10aImmunoglobulin G10aImmunoglobulin M10aleprosy10aSheep1 aKano K1 aAranzazu N1 aNishimaki T1 aConvit J1 aAlbini B1 aMilgrom F00aSerological and immunohistological studies on lepromatous leprosy.  a19-240 v643 a<p>Sera of patients with lepromatous leprosy were studied for the presence of a variety of antibodies and immune complexes (IC). The frequencies of heterophile, Hanganutziu-Deicher and Forssman antibodies were 61 and 43%, respectively, which were significantly higher than those in other diseases. The frequency of antibodies to cardiolipin was 89% and the frequency of rheumatoid factor was 34%. Circulating IC were demonstrated in 54% of the patients' sera by Raji-cell test and in 43% by anti-antibody inhibition test. Analyses of immunoglobulin classes of IC revealed that IgG was predominant in IC of patients with lepra reaction (LR) and IgM in patients without LR. Immune deposits were found in and between cells of dermis in skin biopsy specimens of patients with LR.</p>  a0020-5915