01763nas a2200325   4500000000100000008004100001260000900042653001000051653000900061653001800070653003300088653001900121653001800140653002100158653001100179653001100190653001200201653000900213653001600222653001800238100001200256700001500268700001600283700001200299245008000311300001100391490000700402520101400409022001401423       1980                            d  c198010aAdult10aAged10aComplement C310aComplement C3-C5 Convertases10aComplement C3c10aComplement C410aErythema Nodosum10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aT-Lymphocytes1 aIzumi S1 aSugiyama K1 aMatsumoto Y1 aNagai T00aNumerical changes in T cell subsets (T gamma and T mu) in leprosy patients.  a733-400 v243 a<p>Eighty-six leprosy patients (49 active lepromatous, 24 inactive lepromatous 7 borderline, and 6 tuberculoid) and nine healthy controls were examined for numerical changes in T cell subsets (T gamma and T mu), and complement levels in peripheral blood to determine the roles of T cell subsets and complement in the etiology of leprosy. The percentage and number of T gamma and T mu showed no significant differences among the different clinical groups, but 4 out of 49 active lepromatous, 3 out of 24 inactive lepromatous and 3 out of 7 borderline cases showed a high prcentage of T gamma cells. Serum concentrations of C4, C3c, and C3 activator, an important factor in the alternative pathway of complement activation, were not significantly different among the groups. However, C3 activator and C3c concentrations were significantly high in active lepromatous patients complicated by an immune complex disease called "erythema nodosum leprosum" (ENL) compared with ENL-free active lepromatous leprosy.</p>  a0385-5600