01490nas a2200313   4500000000100000008004100001260001300042653001200055653002100067653001100088653000900099653001200108653000900120653002500129653002300154653001700177653002200194653001800216653001700234100001500251700001900266700001400285245016000299300001000459490000700469050003200476520065400508022001401162       1980                            d  c1980 Jan10aAnimals10aBody Temperature10aFemale10aFoot10aleprosy10aMice10aMycobacterium leprae10aNerve Degeneration10aNerve Fibers10aNeural Conduction10aSciatic Nerve10aTime Factors1 aShetty V P1 aVidyasagar P B1 aAntia N H00aStudy of evolution of nerve damage in leprosy. Part III--Sciatic nerve lesions in mice inoculated with M. leprae with nerve conduction velocity correlates.  a26-470 v52  aInfolep Library - available3 a<p>Non-immunosuppressed Swiss mice inoculated with 5000 M. leprae in each hind foot pad were subjected to nerve conduction velocity studies followed by light and electron microscopy and fibre tease of both sciatic nerves at sequential time intervals from the 4th to the 24th month. The conduction velocity was standardized for basal temperature of 35 degrees C and uninoculated mice were used as controls. Progressive changes were noted in conduction velocity from the 6th post inoculation month and correlated with the ultrastructural changes which were first observed at the 4th month. Fibre teasing showed predominent segmental demyelination.</p>  a0024-1024