01503nas a2200277   4500000000100000008004100001260001300042653001700055653002600072653001100098653002800109653001200137653001600149653002500165653002500190653001500215653001300230100001500243700002100258700001300279245009900292300001000391490000800401520080200409022001401211       1980                            d  c1980 Apr10aCell Nucleus10aEndoplasmic Reticulum10aHumans10aIntercellular Junctions10aleprosy10aMacrophages10aMicroscopy, Electron10aMycobacterium leprae10aSkin Tests10aVacuoles1 aRidley M J1 aBadenoch-Jones P1 aTurk J L00aUltrastructure of cells of the mononuclear-phagocyte series (MPS) across the leprosy spectrum.  a223-70 v1303 a<p>A systematic ultrastructural study of cells of the MPS across the spectrum of leprosy has been carried out. Graded changes in macrophage ultrastructure from the lepromatous to the tuberculoid poles have been shown. Mycobacteria-filled macrophages in lepromatous leprosy are characterised by long cell processes, whereas in borderline tuberculoid leprosy these cells have a rounded appearance and are mainly characterised by numerous intracellular vacuoles. In borderline leprosy, macrophages have an intermediate appearance. Cells of the MPS containing abundant endoplasmic reticulum were only seen in typical "epithelioid cell" tuberculoid granulomas in "BT in reaction" and in the Mitsuda reaction. Epithelioid cell granulomas in other forms of BT leprosy contained activated macrophages.</p>  a0022-3417