01508nas a2200277   4500000000100000008004100001260001300042653001100055653002300066653001200089653001600101653001600117653001800133653002200151653001800173100001400191700001600205700001800221700001400239245012700253856004100380300001100421490000700432520077700439022001401216       1980                            d  c1980 Jun10aHumans10aImmunity, Cellular10aleprosy10aLymphocytes10aMacrophages10aReceptors, Fc10aRosette Formation10aT-Lymphocytes1 aBirdi T J1 aSalgame P R1 aMahadevan P R1 aAntia N H00aRole of macrophages in defective cell mediated immunity in lepromatous leprosy. II. Macrophage and lymphocyte interaction.  uhttp://ila.ilsl.br/pdfs/v48n2a10.pdf  a178-820 v483 a<p>Macrophages from lepromatous patients after phagocytosis of M. leprae showed alteration in their surface property as determined by their ability to express Fc receptors. The same macrophages without intracellular M. leprae show normal Fc receptors. The lepromatous macrophages also show very poor interaction with lymphocytes in the presence of M. leprae while they are able to interact with lymphocytes when exposed to other antigens. These observations along with earlier ones on macrophage defects have indicated a probable reason for defective cell mediated immunity (CMI) in lepromatous leprosy patients. There appears to be a defective macrophage population in lepromatous patients that is unable to process M. leprae antigens and initiate the CMI response.</p>
  a0148-916X