01310nas a2200301   4500000000100000008004100001260001300042653001000055653001100065653001100076653002300087653001200110653002000122653000900142653001600151653001100167653001800178100001400196700001500210700001900225700001200244245008200256300001100338490000700349050003200356520060600388022001400994       1980                            d  c1980 Jul10aAdult10aFemale10aHumans10aImmunity, Cellular10aleprosy10aLeukocyte Count10aMale10aMiddle Aged10aSpleen10aT-Lymphocytes1 aMathias C1 aChacko C J1 aSundar Rao P S1 aJob C K00aT-cell depletion of spleen in patients with longstanding lepromatous leprosy.  a366-730 v52  aInfolep Library - available3 a<p>In 8 autopsied lepromatous patients the spleen was examined histopathologically and their differential cell population was counted in subcapsular area, red pulp and white pulp. There was considerable reduction of lymphocytes and well marked increase in macrophages and plasma cells in the thymus dependent white pulp. In the subcapsular area and the red pulp, although there was an increase in plasma cells and macrophages no significant reduction of lymphocytes was recorded. Therefore, it is suggested that in lepromatous leprosy there is a selective reduction in the number of T lymphocytes.</p>  a0024-1024