01228nas a2200253   4500000000100000008004100001260001300042653001000055653001600065653001100081653001200092653000900104653001100113653001800124100001200142700001300154700001500167245007800182856004100260300001100301490000700312520064100319022001400960       1980                            d  c1980 Sep10aAdult10aHistiocytes10aHumans10aleprosy10aMale10aSpleen10aT-Lymphocytes1 aRea T H1 aBevans L1 aTaylor C R00aThe histopathology of the spleen from a patient with lepromatous leprosy.  uhttp://ila.ilsl.br/pdfs/v48n3a06.pdf  a285-900 v483 a<p>The histopathology of the spleen from a young man with diffuse non-nodular lepromatous leprosy is reported. As judged by this case, other case reports, and necropsy series, involvement of the spleen in lepromatous leprosy is characterized by aggregations of large vacuolated histiocytes, containing individual bacilli and globi, in both the red and white pulp. In the white pulp the histiocytes localize about the arterioles. Findings in the present case, which may represent a comparatively early change, include numerous, small germinal centers containing nonaggregated large, vacuolated histiocytes with intracellular bacilli.</p>  a0148-916X